Powder crystallography on macromolecules
نویسندگان
چکیده
منابع مشابه
Powder crystallography on macromolecules.
Following the seminal work of Von Dreele, powder X-ray diffraction studies on proteins are being established as a valuable complementary technique to single-crystal measurements. A wide range of small proteins have been found to give synchrotron powder diffraction profiles where the peak widths are essentially limited only by the instrumental resolution. The rich information contained in these ...
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Cyclohexene nucleic acids (CeNA) contain a cyclohexene ring instead of the normal -D-2’-deoxyribose. The cyclohexene oligonucleotide GTGTACAC was synthesized using phosphoramidite chemistry and standard protecting groups [1]. CeNA is stable against enzymatic degradation and induces RNaseH activity. CeNA also forms more stable duplexes with RNA than its natural analogues [2] [3]. Crystals of GTG...
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C216 also a potent inhibitor of (Zn/Zn)bLAP. This combined approach provided insights on interaction of bLAP with sulphydryl-containing compounds, showing that metal exchange in site 1 modulates binding to these molecules that, depending on metal nature, may result as enzyme substrates or inhibitors. Work supported by FIRB project from Italian board for education.
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Streptococcal organisms share a well-conserved, binding protein dependent, Multiple Sugar Metabolism (msm) system which is responsible for the transportation and metabolism of multiple sugars. This system is comprised of 8 proteins including 2 membrane proteins (MsmF and MsmG), an ATP-binding protein (MsmK) and the 45KDa sugar-binding lipoprotein MsmE [1]. Both native and selenomethionine deriv...
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Src homology 2 domain-containing protein tyrosine phosphatase [SHP] substrate 1 (SHPS-1), a receptor-type transmembrane glycoprotein whose cytoplasmic region binds and activates the protein tyrosine phosphatases SHP-1 and SHP-2, and thereby modulates multiple cellular functions. Its extracellular region regulates intercellular communication in the neural and immune systems through its associati...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2007
ISSN: 0108-7673
DOI: 10.1107/s0108767307043735